Akademik Veri Yönetim Sistemi
5th International Scientific Research Congress, İstanbul, Türkiye, 18 - 19 Ekim 2025, ss.131-132, (Özet Bildiri)
Multi-walled carbon nanotubes (MWCNT) have been documented to potentially cause impairments in the respiratory, nervous, cardiovascular, and reproductive systems, suppress immunity, and increase oxidative stress, when chronically inhaled; however, their effects on living organisms have not yet been sufficiently elucidated. Therefore, determining the effects of such nanomaterials on model organisms is crucial. In our current study, the pro-antioxidant effects of MWCNTs were investigated in Galleria mellonella larval tissues. Larvae were divided into five groups: control, 50, 100, 500, 1000 ppm. MWCNTs were fed to the larvae via diet throughout their larval development period, and larval homogenates were obtained. Malondialdehyde (MDA), catalase (CAT), glutathione (GSH), and protein levels were determined spectrophotometrically in the homogenates. MDA increased significantly at doses of 100 ppm and above. CAT activity and GSH decreased in all MWCNT groups. Protein decreased substantially at the highest dose. MWCNT affected the pro-antioxidant system in G. mellonella larvae in dose-dependent manner. Results indicate that MWCNT may create biological risks and that G. mellonella may serve as a robust and applicable model for evaluating the nanotoxicological effects of nanomaterials. Furthermore, elucidating the molecular mechanisms underlying the potential health risks of MWCNT could contribute to the design and usage of safer nanomaterials.