The role of miRNAs in cancer: from pathogenesis to therapeutic implications


SEVEN M., Karatas O. F. , Duz M. B. , ÖZEN M.

FUTURE ONCOLOGY, vol.10, no.6, pp.1027-1048, 2014 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Review
  • Volume: 10 Issue: 6
  • Publication Date: 2014
  • Doi Number: 10.2217/fon.13.259
  • Title of Journal : FUTURE ONCOLOGY
  • Page Numbers: pp.1027-1048
  • Keywords: cancer, diagnostic and prognostic biomarkers, miRNAs, oncogenes, tumor suppressor, HUMAN HEPATOCELLULAR-CARCINOMA, CELL LUNG-CANCER, MICRORNA EXPRESSION SIGNATURE, HEMATOPOIETIC STEM-CELLS, TUMOR-SUPPRESSOR GENES, ACUTE MYELOID-LEUKEMIA, BREAST-CANCER, PROSTATE-CANCER, DOWN-REGULATION, LET-7 MICRORNA

Abstract

Cancer is still one of the dominating causes of deaths worldwide, although there have been important enhancements for detection and diagnosis of cancer recently. miRNAs are shown to participate in carcinogenesis of several types of tumors and their aberrant expression of miRNAs has been detected in cell lines, xenografts and clinical samples. miRNAs are thought to target and modulate the expression of more than 60% of human genes, which makes the expressional regulation by miRNAs the most abundant post-transcriptional regulation mode. Here, we have reviewed the most current literature to shed a light on the functions of miRNAs on human carcinogenesis. Possible roles of miRNAs in oncogenesis through both genetic and epigenetic changes occurring during cancer initiation, progression, invasion or metastasis are summarized.