Bone metastasis in endometrial cancer: evaluation of treatment approaches by factors affecting prognosis


Doger E., Cakiroglu Y., Ozdamar O., Ceylan Y., Kole E., Yucesoy I., ...More

EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, vol.37, no.3, pp.407-416, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.12892/ejgo2862.2016
  • Title of Journal : EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
  • Page Numbers: pp.407-416

Abstract

Objective: The purposes of this study were to present an endometrial cancer case with a first sign of bone metastasis, and to reveal factors affecting survival and the appropriate treatment methods for bone metastases. Materials and Methods: A total of 101 case reports that presented with bone metastasis of endometrial cancer were reviewed in this study. Results: Survival time in the patients without surgical treatment for bone metastasis was found to be 12 months (95% CI = 5.89 - 18.10) and 42 months in patients who underwent surgical treatment in addition to one or more of chemo-radio-hormonotherapies (95% CI = 16.58 - 67.41) (p = .006). Histological type of cancer, extra-osseous metastasis, and lack of surgery were the factors significantly affecting survival (p = 0.012, p = 0.002, and p = 0.038, respectively). Conclusion: Histological type and the presence of extra-osseous involvement are important prognostic markers in endometrial cancer patients with bone metastasis. It may be appropriate to implement combination therapies including surgery in the treatment of bone metastases.