EFFECTS OF ASPIRIN AND ACETALDEHYDE ON LONGEVITY AND METAMORPHOSIS DURATION OF Drosophila melanogaster


Keser D., KARATAŞ A.

FRESENIUS ENVIRONMENTAL BULLETIN, vol.21, pp.2758-2765, 2012 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21
  • Publication Date: 2012
  • Title of Journal : FRESENIUS ENVIRONMENTAL BULLETIN
  • Page Numbers: pp.2758-2765

Abstract

In this study, the effects of acetylsalicylic acid (ASA), the active agent in aspirin, and acetaldehyde (AcH), an intermediate metabolite in alcohol metabolism, on life span and some developmental characteristics of Drosophila melanogaster are investigated. Substance administration was done on adult Drosophila through feeding. The effects were investigated using both ASA and AcH individually (ASA; AcH), and together (ASA + AcH). The life span of female D. melanogaster was longer in the experimental groups in which ASA and AcH were administered together. There was no change in the life span of male D. melanogaster. The duration of metamorphosis was prolonged in the ASA and ASA + AcH administered F-1 generation, and AcH administered F-2 generation. Additionally, the survival rate was lower with both individual and combined administration of ASA and AcH in Drosophila melanogaster.