Antagonism of adenosinergic system decrease SWD occurrence via an increment in thalamic NFkB and IL-6 in absence epilepsy


DEDE F. , KARADENİZLİ S. , ÖZSOY Ö. D. , ERALDEMİR F. C. , Sabin D. , ATEŞ N.

JOURNAL OF NEUROIMMUNOLOGY, vol.326, pp.1-8, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 326
  • Publication Date: 2019
  • Doi Number: 10.1016/j.jneuroim.2018.11.004
  • Title of Journal : JOURNAL OF NEUROIMMUNOLOGY
  • Page Numbers: pp.1-8
  • Keywords: Absence epilepsy, Caffeine, Adenosine, NFkB, Cytokines, SPIKE-WAVE DISCHARGES, CYTOKINES, SEIZURES, CAFFEINE, EXPRESSION, RECEPTORS, RATS, STIMULATION, DYSFUNCTION, ASTROCYTES

Abstract

Epilepsy is a major pathological condition, characterized by recurrent seizures and affecting approximately 1% of the population. Many studies have shown a relationship between epilepsy and inflammation. The adenosinergic system contributes to inflammation and epilepsy by regulating the release of neurotransmitters through its various receptors. This study investigates the effect of agonist and antagonist of adenosinergic system on seizure activity and cytokine levels in the WAG/Rij strain, a genetic animal model of absence epilepsy.