JOURNAL OF NEUROIMMUNOLOGY, vol.326, pp.1-8, 2019 (SCI-Expanded)
Article / Article
JOURNAL OF NEUROIMMUNOLOGY
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Absence epilepsy, Caffeine, Adenosine, NFkB, Cytokines, SPIKE-WAVE DISCHARGES, CYTOKINES, SEIZURES, CAFFEINE, EXPRESSION, RECEPTORS, RATS, STIMULATION, DYSFUNCTION, ASTROCYTES
Kocaeli University Affiliated:
Epilepsy is a major pathological condition, characterized by recurrent seizures and affecting approximately 1% of the population. Many studies have shown a relationship between epilepsy and inflammation. The adenosinergic system contributes to inflammation and epilepsy by regulating the release of neurotransmitters through its various receptors. This study investigates the effect of agonist and antagonist of adenosinergic system on seizure activity and cytokine levels in the WAG/Rij strain, a genetic animal model of absence epilepsy.