Antagonism of adenosinergic system decrease SWD occurrence via an increment in thalamic NFkB and IL-6 in absence epilepsy

DEDE F., KARADENİZLİ S., ÖZSOY Ö. D., ERALDEMİR F. C., Sabin D., ATEŞ N.

JOURNAL OF NEUROIMMUNOLOGY, cilt.326, ss.1-8, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 326
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.jneuroim.2018.11.004
  • Dergi Adı: JOURNAL OF NEUROIMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1-8
  • Anahtar Kelimeler: Absence epilepsy, Caffeine, Adenosine, NFkB, Cytokines, SPIKE-WAVE DISCHARGES, CYTOKINES, SEIZURES, CAFFEINE, EXPRESSION, RECEPTORS, RATS, STIMULATION, DYSFUNCTION, ASTROCYTES
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Epilepsy is a major pathological condition, characterized by recurrent seizures and affecting approximately 1% of the population. Many studies have shown a relationship between epilepsy and inflammation. The adenosinergic system contributes to inflammation and epilepsy by regulating the release of neurotransmitters through its various receptors. This study investigates the effect of agonist and antagonist of adenosinergic system on seizure activity and cytokine levels in the WAG/Rij strain, a genetic animal model of absence epilepsy.