Akademik Veri Yönetim Sistemi
JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, cilt.87, sa.2, ss.145-152, 2024 (ESCI)
Objective: Chronic stress is a factor that affects organs/tissues and disrupts homeostasis. This condition can lead to increased oxidative stress, which damages cellular components. Antioxidants attempt to prevent this damage by neutralizing free radicals. Our study aimed to investigate the effect of chronic mild stress on the levels of Catalase (CAT), Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx) and Malondialdehyde (MDA) in serum and liver tissue. Material and Method: In our study, 16 Wistar albino rats were divided into control and experimental groups. The chronic unpredictable mild stress (CUMS) model protocol was employed. The levels of CAT, SOD, GPx, and MDA in serum and liver tissue were measured using the Enzyme -Linked Immunosorbent Assay method. Result: Upon comparison of serum CAT, SOD, GPx, and MDA levels, no statistically significant difference was observed between the control and stress groups (p>0.05). However, when comparing CAT, SOD, GPx, and MDA levels in the liver tissue, a significant increase in the levels of antioxidant enzymes was noted in the stress group (p<0.05). Conclusion: Under chronic stress, liver tissue's antioxidant levels appear to increase. We believe our study may contribute to understanding the connection between stress, free radicals, and antioxidants.