Pulmonary infections in cystic fibrosis: A bibliometric mapping of global research themes (1950-2025)
RESPIRATORY MEDICINE, cilt.257, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 257
- Basım Tarihi: 2026
- Doi Numarası: 10.1016/j.rmed.2026.108823
- Dergi Adı: RESPIRATORY MEDICINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Kocaeli Üniversitesi Adresli: Evet
Özet
Background: Pulmonary infections remain the main cause of morbidity and mortality in cystic fibrosis (CF), despite advances in supportive care and targeted therapies. Since the mid-20th century, research on CFassociated pulmonary infections has expanded substantially, reflecting increasing clinical complexity, evolving pathogens, and antimicrobial resistance. This study aimed to evaluate global research trends related to pulmonary infections in CF between 1950 and 2025 using a bibliometric approach. Methods: A bibliometric analysis was performed using the Scopus database. A disease-centered search strategy was applied without restrictions on pathogens or interventions. Peer-reviewed articles and reviews published up to December 13, 2025 were included, while publications indexed in 2026 and records with missing country affiliation data were excluded. Bibliometric indicators including publication output, journals, countries, institutions, authors, and author keywords were analyzed. Keyword co-occurrence analysis was conducted using VOSviewer to identify major research themes. Results: A total of 8484 publications were included. Research output increased steadily, with a notable rise after the early 2000s and a peak in 2021. Most publications were written in English and classified mainly under Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. The United States, the United Kingdom, and Germany were the most productive countries. Keyword analysis revealed major thematic clusters related to chronic pulmonary disease, antimicrobial therapy and resistance, and pathogen-focused research, with Pseudomonas aeruginosa emerging as the most prominent pathogen. Conclusion: This bibliometric analysis summarizes the evolution of global research on CF-associated pulmonary infections, highlighting sustained emphasis on chronic infection and antimicrobial resistance, and may help guide future research priorities.