Antidepressant-like effects induced by chronic blockade of the purinergic 2x7 receptor through inhibition of non-like receptor protein 1 inflammasome in chronic unpredictable mild stress model of depression in rats

Arıcıoğlu F., Şahinözkartal C., Baştaşkın T., Tüzün E., Kandemir C., Küçükali C., ...Daha Fazla

Clinical Psychopharmacology and Neuroscience, cilt.17, ss.261-272, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17
  • Basım Tarihi: 2019
  • Doi Numarası: 10.9758/cpn.2019.17.2.261
  • Dergi Adı: Clinical Psychopharmacology and Neuroscience
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.261-272
  • Anahtar Kelimeler: Depression, Coomassie Brilliant Blue, ATP receptor, Purinergic P2X7 receptors, Animal models, BRILLIANT BLUE G, NLRP3 INFLAMMASOME, P2RX7 GENE, GLN460ARG POLYMORPHISM, MICROGLIAL ACTIVATION, PSYCHOLOGICAL STRESS, ANIMAL-MODELS, GLOBAL BURDEN, MOUSE MODEL, PATHOPHYSIOLOGY
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Objective: Purinergic 2X7 receptor (P2X7R) activation is known to be involved in pathogenesis of depression. Our aims were to investigate P2X7R-activated inflammasome pathways in parallel with induction of depression and to test the antidepressant-like effects of the selective P2X7R antagonist Brilliant Blue G (BBG) in a rat model of chronic unpredictable mild stress (CUMS).