Antidepressant-like effects induced by chronic blockade of the purinergic 2x7 receptor through inhibition of non-like receptor protein 1 inflammasome in chronic unpredictable mild stress model of depression in rats


Arıcıoğlu F., Şahinözkartal C., Baştaşkın T., Tüzün E., Kandemir C., Küçükali C., ...More

Clinical Psychopharmacology and Neuroscience, vol.17, pp.261-272, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17
  • Publication Date: 2019
  • Doi Number: 10.9758/cpn.2019.17.2.261
  • Title of Journal : Clinical Psychopharmacology and Neuroscience
  • Page Numbers: pp.261-272
  • Keywords: Depression, Coomassie Brilliant Blue, ATP receptor, Purinergic P2X7 receptors, Animal models, BRILLIANT BLUE G, NLRP3 INFLAMMASOME, P2RX7 GENE, GLN460ARG POLYMORPHISM, MICROGLIAL ACTIVATION, PSYCHOLOGICAL STRESS, ANIMAL-MODELS, GLOBAL BURDEN, MOUSE MODEL, PATHOPHYSIOLOGY

Abstract

Objective: Purinergic 2X7 receptor (P2X7R) activation is known to be involved in pathogenesis of depression. Our aims were to investigate P2X7R-activated inflammasome pathways in parallel with induction of depression and to test the antidepressant-like effects of the selective P2X7R antagonist Brilliant Blue G (BBG) in a rat model of chronic unpredictable mild stress (CUMS).