Antidepressant-like effects induced by chronic blockade of the purinergic 2x7 receptor through inhibition of non-like receptor protein 1 inflammasome in chronic unpredictable mild stress model of depression in rats

Arıcıoğlu, Feyza; Şahinözkartal, Ceren; Baştaşkın, Tuğçe; Tüzün, Erdem; Kandemir, C; Küçükali, Cı; Küçükali, Cem; Utkan, TİJEN

doi:10.9758/cpn.2019.17.2.261

Antidepressant-like effects induced by chronic blockade of the purinergic 2x7 receptor through inhibition of non-like receptor protein 1 inflammasome in chronic unpredictable mild stress model of depression in rats

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Arıcıoğlu F., Şahinözkartal C., Baştaşkın T., Tüzün E., Kandemir C., Küçükali C., ...More

Clinical Psychopharmacology and Neuroscience, vol.17, pp.261-272, 2019 (SCI-Expanded)

Publication Type: Article / Article
Volume: 17
Publication Date: 2019
Doi Number: 10.9758/cpn.2019.17.2.261
Journal Name: Clinical Psychopharmacology and Neuroscience
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.261-272
Keywords: Depression, Coomassie Brilliant Blue, ATP receptor, Purinergic P2X7 receptors, Animal models, BRILLIANT BLUE G, NLRP3 INFLAMMASOME, P2RX7 GENE, GLN460ARG POLYMORPHISM, MICROGLIAL ACTIVATION, PSYCHOLOGICAL STRESS, ANIMAL-MODELS, GLOBAL BURDEN, MOUSE MODEL, PATHOPHYSIOLOGY
Kocaeli University Affiliated: Yes

Abstract

Objective: Purinergic 2X7 receptor (P2X7R) activation is known to be involved in pathogenesis of depression. Our aims were to investigate P2X7R-activated inflammasome pathways in parallel with induction of depression and to test the antidepressant-like effects of the selective P2X7R antagonist Brilliant Blue G (BBG) in a rat model of chronic unpredictable mild stress (CUMS).