Isolated Breast Relapse of Acute Lymphoblastic Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation


DEMİRSOY E. T. , ATESOGLU E. B. , TARKUN P. , GEDÜK A. , ERDEM B. E. , Hacihanefioglu A. , et al.

INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION, cilt.32, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 32
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s12288-015-0560-z
  • Dergi Adı: INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION

Özet

Isolated breast relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is less often seen. Chronic graft-versus-host disease (cGVHD) is effective in preventing marrow relapse, but cGVHD seems not to be effective extramedullary relapse (EMR). We report the case of isolated breast relapse after first allo-HSCT for acute lymphoblastic leukemia (ALL). A 47-year-old female was diagnosed with ALL achieved complete remission with salvage chemotherapy and underwent allo-HSCT from an HLA-matched sibling male donor. At 17 months post-transplant, she presented with a bilateral breast masses that confirmed the diagnosis lymphoblast involvement. She had no evidence of leukemia in her marrow that determined 100 % full-donor chimerism when she was relapsed in her both breasts.