Beta-2 microglobulin predicts the outcome after autologous stem cell transplantation in non-Hodgkin lymphoma


Atesoglu E. B. , Haohanefioglu A. , GULBAS Z.

TRANSFUSION AND APHERESIS SCIENCE, cilt.52, ss.65-71, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 52 Konu: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.transci.2014.12.007
  • Dergi Adı: TRANSFUSION AND APHERESIS SCIENCE
  • Sayfa Sayısı: ss.65-71

Özet

Autologous stem cell transplantation (ASCT) is an established therapeutic modality in the treatment of lymphomas, especially in the relapse setting. In the present study, we aimed to define pretransplantation factors including Beta-2 microglobulin (Pm) that influence outcomes following ASCT in patients with non-Hodgkin lymphoma (NHL). We analyzed retrospectively 78 NHL patients who had undergone ASCT from August 2010 to January 2013. The 2-year overall survival (OS) was 70% and the progression-free survival (PFS) was 60%. While remission status less than complete remission (CR) emerged to be a poor prognostic factor for OS in univariate analysis, high beta 2m levels and comorbidity indices revealed to be independent poor risk factors for both OS and PFS. The present study demonstrated that even if the patient is in CR before ASCT if he has high beta 2m, the 2-year OS decreases from 100% to 49%. Moreover, lymphopenia for the first time was demonstrated to predict PFS in ASCT in NHL patients. Our findings suggest that beta 2m at transplantation predict the outcome after ASCT in NHL and further investigation with larger sample sizes is warranted. (C) 2014 Elsevier Ltd. All rights reserved.