Investigation of the mechanism of nicotine-induced relaxation in guinea pig gallbladder

Utkan N. Z., Utkan T., Sarioglu Y., Cantürk N. Z., Okay E.

JOURNAL OF SURGICAL RESEARCH, cilt.110, ss.272-275, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 110
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/s0022-4804(03)00022-2
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.272-275
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Background. Muscular contraction of the gallbladder is the primary determinant of bile delivery into duedonum. Gallbladder filling and emptying are influenced by both inhibitory and excitatory stimuli, and NO plays a key role in normal relaxation. In this study, to determine whether nicotine acts on the gallbladder muscle, the mechanism of its effect on strips of guinea pig gallbladder was studied in vitro.