The total cross sections for the Te-120(p,gamma)I-121 and Te-120(p, n)I-120 reactions have been measured by the activation method in the effective center-of-mass energies 2.47 MeV <= E-c.m.(eff) <= 7.93 MeV and 6.44 MeV <= E-c.m.(eff) <= 7.93 MeV, respectively. The targets were prepared by evaporation of 99.4% isotopically enriched Te-120 on aluminum and carbon backing foils, and bombarded with proton beams provided by the FN tandem accelerator at the University of Notre Dame. The cross sections and S factors were deduced from the observed gamma ray activity, which was detected off-line by two Clover HPGe detectors mounted in close geometry. The results are presented and compared with the predictions of statistical model calculations using the codes NON-SMOKER and TALYS.