Metastatic lobular breast carcinoma positive for syndecan-1 mimicking a plasma cell neoplasm: a case report
Journal of Trends in Medical Investigation (JTMI), cilt.2, sa.1, ss.44-51, 2026 (Hakemli Dergi)
- Yayın Türü: Makale / Vaka Takdimi
- Cilt numarası: 2 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.12345/jtmi.2026.18
- Dergi Adı: Journal of Trends in Medical Investigation (JTMI)
- Derginin Tarandığı İndeksler: Other Indexes
- Sayfa Sayıları: ss.44-51
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Kocaeli Üniversitesi Adresli: Evet
Özet
The metastases of breast cancer to bone marrow can mimic plasma cell neoplasia morphologically due to
presence of plasma cell-like neoplastic cells and even positive staining for a carcinoma metastasis with plasma
cell marker CD138/ Syndecan-1 may cause confusion in diagnosis. This case report details a 71-year-old female
initially suspected of plasma cell myeloma due to hypercalcemia and multiple lytic bone lesions. However,
a bone marrow biopsy revealed syndecan-1 positive metastatic lobular breast cancer mimicking a plasma
cell neoplasm. Bone marrow aspirate smears and the bone marrow biopsy showed plasmacytoid cells that
were strongly positive for syndecan-1, indicating metastatic lobular breast carcinoma. The overexpression of
syndecan-1 was a critical marker in identifying the breast cancer cells, emphasizing the diagnostic challenges
when syndecan-1 positive metastatic lobular BC presents with plasmacytoid features.