Allele frequencies of ACE I/D and CCR5- Δ32 variants in the Jordanian cohort residing in Northern Cyprus

Cobanogullari H., Koyutourk B., Ala'Eddin Daoud M., Fahrioglu U., SAYAN M., Ergoren M. C.

Human Gene, cilt.48, 2026 (ESCI, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1016/j.humgen.2026.201556
  • Dergi Adı: Human Gene
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Anahtar Kelimeler: ACEI/D polymorphism, Allele frequency, CCR5-Δ32 variant, Genetic diversity, Jordanian cohort
  • Kocaeli Üniversitesi Adresli: Evet

Özet

BackgroundGenetic variants such as ACE I/D and CCR5-Δ32 have been associated with variable susceptibility to infectious diseases. Data from Arab populations remain scarce.ObjectiveTo determine the allele frequencies of ACE I/D and CCR5-Δ32 polymorphisms in a Jordanian cohort residing in Northern Cyprus.MethodsA total of 158 Jordanian students (135 males, 23 females; mean age 24.3 ± 2.3 years) were genotyped using PCR and agarose gel electrophoresis. Allele and genotype distributions were calculated and tested for Hardy–Weinberg equilibrium (HWE).ResultsThe CCR5-Δ32 allele was observed at a frequency of 0.03, exclusively in heterozygotes. The ACE I allele was observed at a frequency of 0.60, and the D allele at 0.40. Both loci were in HWE.ConclusionThis study provides descriptive genotype and allele frequency data for the CCR5-Δ32 and ACE I/D variants in a Jordanian cohort residing in Northern Cyprus. The findings contribute reference data for future pharmacogenomic and population genetics research in Middle Eastern populations and highlight population-specific genetic variability. Further studies incorporating more representative and larger cohorts and clinical data are required to clarify potential clinical or biological implications.