Effect of maximum-tolerated doses and low-dose metronomic chemotherapy on serum vascular endothelial growth factor and thrombospondin-1 levels in patients with advanced nonsmall cell lung cancer

TAŞ F., DURANYILDIZ H. D., Soydinc H. O., Cicin I., Selam M., Uygun K., ...More

CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol.61, no.5, pp.721-725, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 5
  • Publication Date: 2008
  • Doi Number: 10.1007/s00280-007-0526-4
  • Journal Name: CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.721-725
  • Keywords: metronomic chemotherapy, MTD chemotherapy, serum, VEGF, TSP1, ANGIOGENESIS
  • Kocaeli University Affiliated: Yes

Abstract

Background Angiogenesis is regulated by a balance of both angiogenic inducers and inhibitors. This study was designed to evaluate the effect of both maximum-tolerated doses (MTD) and low-dose metronomic chemotherapy (LDM) on serum vascular endothelial growth factor (VEGF), thrombospondin-1 (TSP1) and VEGFR1 concentrations in patients with advanced nonsmall cell lung cancer.