The stereochemistry of the Grignard reaction of steroidal 4,5-epoxy-3-ketones


Uyanik C. , Malay A., Ayna A., Hanson J., Hitchcock P.

STEROIDS, cilt.70, sa.2, ss.71-75, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 70 Konu: 2
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.steroids.2004.09.002
  • Dergi Adı: STEROIDS
  • Sayfa Sayıları: ss.71-75

Özet

The stereochemistry of the addition of methylmagnesium bromide to a steroidal 4,5-epoxy-3-ketone has been shown to be determined by the stereochemistry of the epoxide. The epoxidation to the corresponding 3-alkyl-3-hydroxy-4-enes by per-acid was determined by the stereochemistry of the allylic alcohol. (C) 2004 Elsevier Inc. All rights reserved.