The stereochemistry of the Grignard reaction of steroidal 4,5-epoxy-3-ketones


Uyanik C., Malay A., Ayna A., Hanson J., Hitchcock P.

STEROIDS, cilt.70, ss.71-75, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

The stereochemistry of the addition of methylmagnesium bromide to a steroidal 4,5-epoxy-3-ketone has been shown to be determined by the stereochemistry of the epoxide. The epoxidation to the corresponding 3-alkyl-3-hydroxy-4-enes by per-acid was determined by the stereochemistry of the allylic alcohol. (C) 2004 Elsevier Inc. All rights reserved.