The Value of Immunohistochemical Methods and Preoperative Magnetic Resonance Imaging Findings in Diagnosis of IDH1 Mutant Glioblastomas.

Kiraz U., Vural Ç., Turan G., Alparslan B., Dervisoglu E.

Turkish neurosurgery, vol.32, no.2, pp.228-236, 2022 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.5137/1019-5149.jtn.33708-21.3
  • Journal Name: Turkish neurosurgery
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.228-236
  • Keywords: Glioblastoma, IDH1 mutation, Immunohistochemistry, Polymerase chain reaction, Magnetic resonance imaging, CENTRAL-NERVOUS-SYSTEM, MUTATIONS, BRAIN, CLASSIFICATION, SURVIVAL, GLIOMAS, TUMORS, BIOMARKER, ANTIBODY, ATRX
  • Kocaeli University Affiliated: Yes

Abstract

AIM: To assess the presence of isocitrate dehydrogenase (IDH) 1 mutation in glioblastomas using real-time polymerase chain reaction (RT-PCR), which is the gold standard in the diagnosis of IDH1 mutation; by immunohistochemistry (IHC), which is available in most of the pathology laboratories; and by preoperative magnetic resonance imaging, which is a non-invasive method. We also investigated the relationship between these methods and their usability in routine practice.