The Value of Immunohistochemical Methods and Preoperative Magnetic Resonance Imaging Findings in Diagnosis of IDH1 Mutant Glioblastomas.
Turkish neurosurgery, cilt.32, sa.2, ss.228-236, 2022 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 2
- Basım Tarihi: 2022
- Doi Numarası: 10.5137/1019-5149.jtn.33708-21.3
- Dergi Adı: Turkish neurosurgery
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.228-236
- Anahtar Kelimeler: Glioblastoma, IDH1 mutation, Immunohistochemistry, Polymerase chain reaction, Magnetic resonance imaging, CENTRAL-NERVOUS-SYSTEM, MUTATIONS, BRAIN, CLASSIFICATION, SURVIVAL, GLIOMAS, TUMORS, BIOMARKER, ANTIBODY, ATRX
- Kocaeli Üniversitesi Adresli: Evet
Özet
AIM: To assess the presence of isocitrate dehydrogenase (IDH) 1 mutation in glioblastomas using real-time polymerase chain reaction (RT-PCR), which is the gold standard in the diagnosis of IDH1 mutation; by immunohistochemistry (IHC), which is available in most of the pathology laboratories; and by preoperative magnetic resonance imaging, which is a non-invasive method. We also investigated the relationship between these methods and their usability in routine practice.