Fluorescein sodium-guided surgery in glioblastoma multiforme: a prospective evaluation


Koc K., ANIK İ. , ÇABUK B. , CEYLAN S.

BRITISH JOURNAL OF NEUROSURGERY, vol.22, no.1, pp.99-103, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 1
  • Publication Date: 2008
  • Doi Number: 10.1080/02688690701765524
  • Title of Journal : BRITISH JOURNAL OF NEUROSURGERY
  • Page Numbers: pp.99-103

Abstract

We have evaluated the influence of fluorescein-guided resection on gross total resection (GTR) and survival in a series of patients with GBM. Group 1 consisted of 47 patients given fluorescein and group 2 comprised 33 patients, on whom fluorescein was not used. Median survival time was 43.9 weeks in the patients given fluorescein and was 41.8 weeks in the non-fluorescein group. There was no statistically significant difference in survival between the two groups. However, the extent of resection had a powerful influence on the median survival time. Survival was 34.3 weeks after partial resection and 46.5 after GTR. Our data shows that the use of fluorescein injection is a simple procedure, which allows a significant increase in the number of patients having GTR (83 vs. 55%). Our findings are similar to a recently published multicentre Phase III randomized trial in which 5-aminolevulinic acid was used to facilitate resection of malignant glioma.